Phenytoin
sodium, Dilantin, is a commonly used antiepileptic. Phenytoin acts to
suppress the abnormal brain activity seen in seizure by reducing electrical
conductance among brain cells by stabilizing the inactive state of
voltage-gated sodium channels. Aside from seizures, it is an option in the
treatment of trigeminal neuralgia in the event that carbamazepine or other
first-line treatment seems inappropriate.
It is sometimes considered a class 1b antiarrhythmic.
Phenytoin, 5,5-diphenylimidazolidinedione
is synthesized in two different ways. The first involves a base catalyzed
addition of urea to benzil followed by a benzilic acid rearrangement (1,2
phenyl migration) to form the desired product. This is known as the Biltz
Synthesis of phenytoin. (Wikipedia)
Step by step to synthesis Dilantin
The synthesis processes of
5,5-diphenylhydantion are as follow:
The processes could be divided into three
steps:
No comments:
Post a Comment