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Saturday, November 17, 2012

Quinine, Quinidine and Tonic Water - Organic Compound - Lu Le Laboratory

Quinine is a white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties and an extremely bitter taste. It is a stereoisomer of quinidine which is an antiarrhythmic. Quinine contains two major fused-ring systems: the aromatic quinoline and the bicyclic quinuclidine.

                                                  Quinine                    Quinidine

Though it has been synthesized in the lab, quinine occurs naturally in the bark of the cinchona tree. The medicinal properties of the cinchona tree were originally discovered by the Quechua, who are indigenous to Peru and Bolivia; later, the Jesuits were the first to bring the cinchona to Europe.
Quinine was the first effective treatment for malaria caused by Plasmodium falciparum, appearing in therapeutics in the 17th century. It remained the antimalarial drug of choice until the 1940s, when other drugs replaced it that have less unpleasant side effects. Since then, many effective antimalarials have been introduced, although quinine is still used to treat the disease in certain critical circumstances, such as severe malaria, and in impoverished regions due to its low cost. Quinine is available with a prescription in the United States and over-the-counter, in minute quantities, in tonic water.

 Tonic Water

Quinine is also used to treat lupus and arthritis. Quinine was also frequently prescribed in the US as an "off-label" treatment for nocturnal leg cramps, but this has since been prohibited, in effect, by an FDA statement warning against the practice. Chloroquine was developed synthetically for use against malaria and has been an effective way to treat this disease.


Quinine is very sensitive to ultraviolet light (UV) and will fluoresce in direct sunlight, due to its highly conjugated resonance structure.

 Tonic Water under Long Wave UV(365nm) Light

  Tonic Water under Short Wave UV(254nm) Light

 Tonic Power!!!! (It is really bitter!)


2.      Wikipedia - Quinine

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